Kalaupapa (Hawaiian pronunciation: [kəlɐwˈpɐpə]) is a small unincorporated community on the island of Molokaʻi, within Kalawao County in the U.S. state of Hawaii. In 1866, during the reign of Kamehameha V, the Hawaii legislature passed a law that resulted in the designation of Molokaʻi as the site for a leper colony, where patients who were seriously affected by leprosy (also known as Hansen's disease) could be quarantined, to prevent them from infecting others. At the time, the disease was little understood: it was believed to be highly contagious and was incurable until the advent of antibiotics. The communities where people with leprosy lived were under the administration of the Board of Health, which appointed superintendents on the island.