Lewis Thompson Woodruff (March 5, 1816 – May 25, 1869) was an officer in the Confederate States Army during the American Civil War. He was born in Hartford, Connecticut, but moved to Mobile, Alabama in 1839. He entered Alabama state service on April 24, 1861 as captain of the "Mobile Rifles", which was designated Company K, 3rd Alabama Infantry. Woodruff was so well thought of that an offshoot of his company took his name, and the "Woodruff Rifles" fought in the 21st Alabama Infantry. The 3rd Alabama was organized at Montgomery, Alabama and was the first Alabama regiment to make the trek to the seat of war in Virginia, where it mustered into Confederate service at Lynchburg on May 4th.