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Louis J. and Harriet Rozier House is a historic home located at De Soto, Jefferson County, Missouri. It was built in 1887, and is a two-story, asymmetrical, Queen Anne style frame dwelling. It sits on a rock-faced limestone foundation and has a hipped roof and lower cross gables. It features a one-story wraparound porch, spindlework, and fishscale shingles. It was listed on the National Register of Historic Places in 2006.