Luisa María Francisca de Guzmán y Sandoval (Portuguese: Luísa Maria Francisca de Gusmão; 13 October 1613 – 27 February 1666) was a queen consort of Portugal. She was the spouse of King John IV, the first Braganza ruler, as well as the mother of two kings of Portugal (Afonso VI and Peter II) and a queen of England (Catherine of Braganza). She served as regent of Portugal de jure from 1656 until 1662, and de facto until her death in 1666.