Lyons and Yosco were an American comedy duo, consisting of Italian American musicians George Lyons and Bob Yosco. They were defined by the Ottawa Evening Journal "the finest pair of Italian street musicians playing in the Vaudeville ranks." They toured the United States from 1909 into 1923, doing a musical and comedy act. The News Journal described their performance, saying they were "the best vocalists and instrumentalists of the street variety on the stage, proved intensely interesting, while their droll comedy kept the audience laughing much of the time."