Mélidore et Phrosine is an opera by the French composer Étienne Méhul. It takes the form of a drame lyrique (a type of opéra comique) in three acts. The libretto, by Antoine Vincent Arnault, is loosely based on the myth of Hero and Leander. The work was first performed at the Théâtre Favart in Paris on 6 May 1794. It is an important example of early Romantic opera.