The Macy–Colby House is a historically significant saltbox house at 257 Main Street in Amesbury, Massachusetts. It is a historic house museum and has been listed on the National Register of Historic Places since 2008. In addition to its great age, it is notable for its association with Thomas Macy, an early settler of Nantucket and the subject of a poem by John Greenleaf Whittier, and for its long association with the locally significant Colby family.