Mamia II Gurieli (-1625/1627) is a 17th-century Georgian prince that ruled over the Principality of Guria in Western Georgia. Son of Prince George II, he succeeded his father in 1600 after spending a decade as head of Gurian troops. As Prince, he distinguished himself as a staunch supporter of closer relations with other Georgian states and an enemy of the Ottoman Empire. However, his policy failed as he was forced to remain under Turkish influence, while his ties with the Kingdom of Imereti progressively declined until an armed conflict and his assassination in 1625.