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Margaret Campbell Mann Lesley (1891-1988) was an American cytologist and geneticist who specialized in plant breeding cytogenetics. Her primary work focused on cytological analyses of tomatoes and citrus. She was an active research assistant to Howard B. Frost (1881-1969), an Associate Plant Breeder at the Citrus Experiment Station, and to James W. Lesley (1888-1982), her husband, whom she extensively collaborated and conducted research on tomato breeding.