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Margaret Nairne, 2nd Baroness Nairne, later Countess of Nairne, (1669 - 14 November 1747) was a Scottish noblewoman at the turn of the 18th century and active in the Jacobite cause for its duration. Her husband, William Murray, 2nd Lord Nairne, was condemned to death for his role in plans for a Scottish rebellion supported by neighbouring France; Lady Margaret travelled from Edinburgh to London to agitate in person for her husband's reprieve from execution, which was eventually successful.