Mariana of Austria (Spanish: Mariana de Austria) or Maria Anna (24 December 1634 – 16 May 1696) was Queen of Spain as the second wife of her uncle Philip IV of Spain from their marriage in 1649 until Philip died in 1665. She was then appointed regent for their three-year-old son Charles II, and due to his ill health remained an influential figure until her own death in 1696.