Maryland Route 180 (MD 180) is a state highway in the U.S. state of Maryland. Known for most of its length as Jefferson Pike, the state highway runs 14.95 miles (24.06 km) from U.S. Route 340 (US 340) in Knoxville east to Ballenger Creek Pike and Interstate 70 (I-70) in Frederick. MD 180 is the old alignment of US 340 through Knoxville, Petersville, and Jefferson in the Middletown Valley of western Frederick County. The state highway was originally constructed in the early 1910s and designated US 340 in 1927. MD 180 was assigned to the highway bypassed by the US 340 freeway between Sandy Hook in far southern Washington County and Jefferson in the mid-1960s. The state highway was extended east to Frederick and south along Ballenger Creek Pike (former MD 351) after the US 340 freeway was com