Melnea Agnes Cass (née Jones; June 16, 1896 – December 16, 1978) was an American community and civil rights activist. She was deeply involved in many community projects and volunteer groups in the South End and Roxbury neighborhoods of Boston and helped found the Boston local of the Brotherhood of Sleeping Car Porters. She was active in the fight to desegregate Boston public schools, as a board member and as president of the Boston chapter of the National Association for the Advancement of Colored People (NAACP). As a young woman, Cass also assisted women with voter registration after the passage of the Nineteenth Amendment. She was affectionately known as the "First Lady of Roxbury."