Meshoppen Creek is a tributary of the Susquehanna River in Susquehanna and Wyoming counties, Pennsylvania, in the United States. It is approximately 30.6 miles (49.2 km) long and flows through Bridgewater Township, Dimock Township, and Springville Township in Susquehanna County and Lemon Township, Washington Township, Meshoppen Township, and Meshoppen in Wyoming County. The watershed of the creek has an area of 114 square miles (300 km2). It is possible to canoe on 17.0 miles (27.4 km) of Meshoppen Creek.