Mississippi Highway 161 (MS 161) is a state highway designation for three highways in the U.S. state of Mississippi, consisting of old alignments of U.S. Route 61 (US 61). Totaling at 19.872 miles (31.981 km), the three sections are located in Bolivar, Coahoma, and Desoto counties. The Bolivar County section, designated in 2000, travels from Merigold to Mound Bayou and Shelby. In Coahoma County, MS 161 was designated in 2004 and runs through Clarksdale and Lyon. In Desoto County, MS 161 travels through the town of Walls and was created in 1999.