Mooresville is a town in Limestone County, Alabama, United States, located southeast of the intersection of Interstate 565 and Interstate 65, and north of Wheeler Lake. The town is between Huntsville and Decatur, and is part of the Huntsville-Decatur Combined Statistical Area; its population as of the 2010 census is 53, down from 59 in 2000. The town was the primary filming location for Disney's live action production of Tom and Huck (1995).