Muhammad Khan was a son of Khizr Khoja and was Khan of Moghulistan from 1408 to 1415. Muhammad Khan's brothers included Shams-i-Jahan. After Esen Buqa Khan, excepting Tughlugh Timur Khan, there was no one left in the country of the Moghuls who was of the first rank of Khákáns. After the death of Tughlugh Timur, Amir Kamaruddin murdered all of Tughlugh's sons, so that there was no one left but Khizr Khwaja Khan. This last Khan left many sons and grandsons; the details of the lives of all of them have not, however, been preserved in the Moghul traditions.