North Main Street Historic District is a national historic district located at Poplar Bluff, Butler County, Missouri. It encompasses 19 contributing buildings and 1 contributing structure in a predominantly residential section of Poplar Bluff. The district developed between about 1880 and 1954, and includes representative examples of Queen Anne, Neo-Classical Revival, Colonial Revival, Late Gothic Revival, and Bungalow / American Craftsman style architecture. Located in the district is the separately listed Moore-Dalton House. Other notable buildings include the Holy Cross Episcopal Church (c. 1902) and the Zion Lutheran Church (c. 1947).