The North River is an 82-mile-long (132 km) river in northeastern Missouri, the United States. It rises in Knox County at 40°03′30″N 92°15′26″W / 40.05833°N 92.25722°W (northwest of Novelty) and flows southeast and east through Shelby and Marion counties, emptying into the Mississippi River at 39°51′21″N 91°26′41″W / 39.85583°N 91.44472°W between West Quincy and Hannibal.