North Third Street Historic District is a national historic district located at Louisiana, Pike County, Missouri. The district encompasses 61 contributing buildings, one contributing site, and contributing structure in a predominantly residential section of Louisiana. It developed between about 1843 and 1935 and includes representative examples of Greek Revival, Gothic Revival, Italianate, Queen Anne, Colonial Revival, and Bungalow/American Craftsman style architecture. Located in the district are the separately listed Louisiana Public Library and Luce-Dyer House. Other notable buildings include the William C. Hardin House (c. 1843), James H. Johnson House (c. 1861), Edward G. McQuie House (c. 1858), St. Joseph's Catholic Church (1874), and Frank Boehm, Jr. House.