Prafulla Kumar Sen MD (7 December 1915 – 22 July 1982) was an Indian vascular and cardiothoracic surgeon, who led the first human heart transplant procedure in India in 1968 and became the fourth surgeon in the world to carry out this operation. It was also the sixth attempt at this procedure in the world. Sen was, in addition, a poet and painter. His paintings were displayed once in the United States, and twice in India.