Patrick Spence (11 February 1898 – 22 November 1983) was a South African tennis player. He was born in Queenstown, South Africa. He competed mainly in Great Britain and found his form in hard court tournaments. He notably won the mixed doubles championships at Wimbledon in 1928 with Elizabeth Ryan and at the French Open in 1931 with Betty Nuthall. He also competed at the 1924 Summer Olympics.