Pedro Álvarez de Toledo y Zúñiga (13 July 1484 – 21 February 1553) was a Spanish politician. The first effective Spanish viceroy of Naples, in 1532–1552, he was responsible for considerable social, economic and urban improval in the city and southern Italian kingdom in general. He was the father-in-law of Cosimo I de' Medici, Grand Duke of Tuscany.