Pendleton Historic District in Pendleton, South Carolina is a historic district which is located mostly in Anderson County, South Carolina and partly in Pickens County, South Carolina. The district was listed on the National Register of Historic Places in 1970. The historic district includes the town of Pendleton and its immediate surroundings plus a large tract west towards Lake Hartwell to include the Hopewell Keowee Monument and the Treaty Oak Monument. The entire historic district covers an area of over 6,300 acres (25 km2).