Pennsylvania Route 563 (PA 563) is a state highway in the U.S. state of Pennsylvania. The route runs 21.15 mi (34.04 km) from PA 63 in Upper Salford Township northeast to PA 412 in Nockamixon Township. The road runs through mostly rural areas in the northern parts of Montgomery and Bucks counties. Along the way, the route passes through the northern part of Perkasie and forms a concurrency with PA 313 in East Rockhill Township. North of here, PA 563 runs through Nockamixon State Park, heading to the northwest of Lake Nockamixon.