The Plan of Ayutla was the 1854 written plan aimed at removing conservative, centralist President Antonio López de Santa Anna from control of Mexico during the Second Federal Republic of Mexico period. Initially, it seemed little different than other political plans of the era, but it is considered to be the first act of the Liberal Reform in Mexico. It was the catalyst for revolts in many parts of Mexico, which led to the resignation of Santa Anna from the presidency, never to vie for office again. The next Presidents of Mexico were the liberals, Juan Álvarez, Ignacio Comonfort, and Benito Juárez. The new regime would then proclaim the 1857 Mexican Constitution, which implemented a variety of liberal reforms.