Pocotaligo is an unincorporated community located in northeastern Jasper County, South Carolina, United States, close to the border of Beaufort County. The community takes its name from the Pocotaligo River, a small tidal creek that separates Jasper and Beaufort counties. Although historically significant, Pocotaligo today primarily serves as a junction point between U.S. Highway 17, U.S. Highway 17 Alternate and U.S. Highway 21. These roads lead to Interstate 95 at Point South and Yemassee, which have over time eclipsed Pocotaligo in population and importance. Very few people live in the community today.