Prince Alfred of Great Britain (22 September 1780 – 20 August 1782) was the fourteenth child and ninth and youngest son of George III and his queen consort, Charlotte of Mecklenburg-Strelitz. In 1782, Alfred, who had never enjoyed robust health, became unwell after his inoculation against the smallpox virus. His early death, along with the demise of his brother Prince Octavius six months later, deeply distressed the royal family. In his later bouts of madness, King George imagined conversations with both of his youngest sons.