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Ralph Mackerell (died 1436) was an English landowner and Member of Parliament. On his father's death he inherited an estate at Wilsthorpe, Nottinghamshire but also owned estates in a number of other Nottinghamshire manors. He was appointed Sheriff of Nottinghamshire and Derbyshire for 1411, 1419 and 1422. He was Escheator for Nottinghamshire and Derbyshire for 1416-1417 and 1426 and deputy keeper of Nottingham castle from 1421. He was a Justice of the Peace for Nottinghamshire from 1422 to 1423.