Regina Jacobs (born August 28, 1963 in Los Angeles) is an American former middle-distance runner from Los Angeles. She had an extended career that included two IAAF World Championships in Athletics silver medals and an indoor world championship at the age of 39. Three months later, her career ended after winning what would have been a fifth straight National Championship in the 1500 meters when she was disqualified and banned for doping related to the BALCO scandal.