René Louis De Rouen (January 7, 1874 – March 27, 1942) was a U.S. Representative from Louisiana. Born on a farm near Ville Platte, then in St. Landry Parish (since the seat of government of Evangeline Parish), De Rouen attended private and public schools, and St. Charles College in Grand Coteau, Louisiana. He graduated in 1892 from Holy Cross College in New Orleans. De Rouen engaged in mercantile pursuits, banking, and farming. He served as delegate to the Louisiana constitutional convention in 1921.