René Louiche Desfontaines (14 February 1750 – 16 November 1833) was a French botanist. Desfontaines was born near Tremblay in Brittany. He attended the and in 1773 went to Paris to study medicine. His interest in botany originated from lectures at the Jardin des Plantes given by Louis Guillaume Lemonnier. He excelled in his new interest and was elected to the French Academy of Sciences in 1783. He was also a member of the Académie Nationale de Médecine. The genera Desfontainia and Fontanesia are named for this author.