Roxana is a village in Madison County, Illinois, United States. The population was 1,542 at the 2010 census. A majority of the land in Roxana is taken up by the Wood River Refinery, an oil refinery operated by Phillips 66. The refinery was originally built and owned by Shell Oil. As of 2016, the refinery is capable of refining 314,000 barrels (49,900 m3) of oil per day to produce gasoline, jet fuel, diesel, asphalt, propane, and other products, and supplies part of the St. Louis, Chicago, Indiana and Ohio regions.