Rufus Amis House and Mill is a historic home and grist mill and national historic district located near , Granville County, North Carolina. The house was built about 1855, and is a 1 1/2-story, "L"-shaped Gothic Revival / Greek Revival style frame dwelling. It has a roof with six gables and delicately sawn bargeboards. Also on the property are the contributing smokehouse, icehouse (later a striphouse), privy, barn, chicken house, corn crib, mill race, former dwelling, and 3 1/2-story grist mill. It was listed on the National Register of Historic Places in 1988.