SMS V43 was a V25-class Large Torpedo Boat (Großes Torpedoboot) of the Imperial German Navy, that served during the First World War. V43 was built by AG Vulcan at their Stettin shipyard from 1914–1915, entering service on 28 May that year. V43 took part in operations in the North Sea, the English Channel and the Baltic Sea. She survived the war, and was interned at Scapa Flow, surviving the Scuttling of the German fleet at Scapa Flow. V43 was allocated to the US Navy, and was sunk as a target on 15 July 1921.