Saizana (unvocalized Ge'ez: ሠዐዘነ śʿzn) was the brother of King Ezana of Axum, who changed the official religion of the Axumite Kingdom to Christianity. That kingdom abutted the Red Sea. According to the historian Tyrannius Rufinus, he was converted to Christianity with his brother Ezana by the missionary Frumentius. With his brother, he resisted the attempts of the Christian Roman emperor Constantius II to relieve Frumentius of his post as bishop and replace him with an Arian (which was a different sect of Christianity).