Sami El-Sheshini (Arabic: سامي الشيشيني; born 23 January 1972) is an Egyptian former professional footballer who played as a defender. El-Sheshini spent most of his career playing for Egyptian Premier League side Zamalek SC. He played for the Zamalek side that won the 2000 African Cup Winners' Cup. El-Sheshini made several appearances for the Egypt national football team, including three appearances at the 1998 African Cup of Nations finals. He also played for Egypt at the 1991 FIFA World Youth Championship in Portugal and the 1992 Summer Olympics in Barcelona.