Santillane is a historic home located near Fincastle, Botetourt County, Virginia. It was built in 1795, and consists of a two-story high, three bay by four bay, main block with a one-story, rear kitchen wing. It is constructed of brick and is in the Greek Revival style. The house has a shallow hipped roof and tetrastyle two-story front portico dated to the early 20th century. Also on the property is a contributing stone spring house. The house stands on a tract purchased by Colonel George Hancock (1754–1820) in 1795. The kitchen wing may date to his period of ownership.