Santo Domingo Tonalá is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of km².It is part of the Huajuapan District in the north of the Mixteca Region. As of 2005, the municipality had a total population of . Santo Domingo Tonala is located about 50 km from Huajuapan de leon. Santo Domingo Tonala has been working with its community to maintain its Flora and Fauna by educating schools. Also, along city limits many signs have been posted to encourage people, tourist and surrounding towns to take care of the environment.