The House of Sapieha ([saˈpʲjɛxa]; Belarusian: Сапега, Sapieha; Lithuanian: Sapiega) is a Polish-Lithuanian noble and magnate family of Lithuanian and Ruthenian origin, descending from the medieval boyars of Smolensk and Polotsk. The family acquired great influence and wealth in the Polish–Lithuanian Commonwealth during the 16th century.