The Second Margrave War (German: Zweiter Markgrafenkrieg) was a conflict in the Holy Roman Empire between 1552 and 1555. Instigated by Albert Alcibiades, Margrave of Brandenburg-Kulmbach and Brandenburg-Bayreuth, it involved numerous raids, plunderings, and the destruction of many towns and castles in the empire, especially in Franconia. Other towns in other areas were also affected, such as Mainz, Worms, Oppenheim, Metz, Verdun, Frankfurt, and Speyer.