Sir Francis Wyndham, 1st Baronet (c. 1612 – 15 July 1676) of Trent, Dorset was an English soldier and politician who sat in the House of Commons of England at various times from 1640 until his death in 1676. During the First English Civil War, he served as a colonel in the Royalist army and helped Charles II of England escape to France after his defeat in the 1651 Third English Civil War.