Smith's Hundred or Smythe's Hundred was a colonial English settlement in the Province of Virginia, in the modern United States of America. It was one of the original James River plantations named after the treasurer of the Virginia Company, Sir Thomas Smith. It was settled by the English in 1617 and after 1620, was known as Southampton Hundred in honor of the Earl of Southampton. The site was originally home to a village of the Paspahegh Indians. They were located along the north bank of James River.