St. James House of Prayer Episcopal Church, also known as the Episcopal House of Prayer, is an active Episcopal parish and historic church building in Tampa, Florida, United States. It is located at 2708 Central Avenue in the city's Tampa Heights neighborhood. On February 21, 1991, the building was added to the U.S. National Register of Historic Places. The structure is also included as an official contributing property within the Tampa Heights Historic District, which was declared a Historic District nationally by the United States Department of the Interior on August 4, 1995, and locally by the city of Tampa on September 7, 2000. Additionally, the building is one of only two churches to have been designated a Local Landmark Structure by the city of Tampa.