Thomas William Humes (April 22, 1815 – January 16, 1892) was an American clergyman and educator, active in Knoxville, Tennessee, during the latter half of the 19th century. Elected rector of St. John's Episcopal Church in 1846, Humes led the church until the outbreak of the Civil War, when he was forced to resign due to his Union sentiments. He was named president of East Tennessee University in 1865, and during his tenure, he led the school's expansion and transition into the University of Tennessee. Humes later served as the first librarian of the Lawson McGhee Library, and published a book about East Tennessee's Unionists entitled, The Loyal Mountaineers of Tennessee.