A significant tornado outbreak sequence took place from March 24–28, 2021 in the Southern United States just one week after another outbreak affected similar regions. There were 43 tornadoes confirmed across 11 states, with the bulk of activity primarily on March 25, which resulted in the Storm Prediction Center (SPC) issuing its second high-risk outlook for the month of March, as well as the second high-risk outlook for 2021. Several intense tornadoes touched down on that day, including ones that prompted the issuance of rare tornado emergencies near Hoover, Alabama, Brent and Centreville, Alabama, and in the Newnan, Georgia area. March 27 also saw widespread tornado activity mainly across East Texas, Southern Arkansas, Louisiana, and Western Tennessee with several strong tornadoes touchi