Toshio Ōtsu (Japanese: 大津敏男) (October 26, 1893 – December 27, 1958) was the last Director of the Karafuto Agency (1943 – November 11, 1947). After the end of his tenure, the Agency was abolished with the incorporation of Karafuto into the Soviet Union. He was Governor of Saitama Prefecture (1942–1943). He was a graduate of the University of Tokyo. After the defeat of the Empire of Japan in World War II, he was interned by the Soviet authorities.