U.S. Route 220 (US 220) is a spur route of US 20. It runs in a north–south layout in the eastern United States, unlike its parent route as well as conventionally even-numbered highways which run east-west. US 220 extends for 678 miles (1,091 km) from an intersection with US 1 in Rockingham, North Carolina, to its interchange with the Southern Tier Expressway (Interstate 86 and New York State Route 17) in South Waverly, Pennsylvania. Some sections of the route are part of the Appalachian Development Highway System's Corridor O as well as I-73 in North Carolina. US 220 is designated as a spur route of US 20 but the route does not intersect US 20 or connect to other spurs of US 20.