U.S. Highway 26 (US‑26) is an east–west highway in western Nebraska. It enters the state from Wyoming just west of Henry. The eastern terminus of US‑26 is in Ogallala at an interchange with Interstate 80 (I-80). The highway largely parallels the North Platte River for the majority of its route in Nebraska and as such, runs at a northwest-southeast angle. The highway also parallels the original paths of the Oregon Trail, the California Trail and the Mormon Pioneer Trail.