U.S. Route 301 (US 301) in the state of Maryland is a major highway that runs 122.85 miles (197.71 km) from the Governor Harry W. Nice Memorial Bridge over the Potomac River into Virginia northeast to Delaware. It passes through three of Maryland's four main regions: Southern Maryland, the Baltimore-Washington Metropolitan Area, and the Eastern Shore. US 301 serves mainly as a bypass of Baltimore and Washington, D.C. from Virginia to Delaware.